TECHNOLOGY_Shanghai Genesense Technology Inc.

With a visionary tech approach, GeneSense embarked on a proactive exploration of the profound integration of AI and gene sequencing as early as 2018, positioned as a pivotal facet of its core technological advancement and groundbreaking strategy. It unveils the industry's inaugural high-throughput genetic sequencer, boasting AI deep learning algorithm technology. Based on the proprietary development from GeneSense, this cutting-edge platform harnesses the formidable capabilities of AI neural networks to meticulously analyze genetic data, yielding unparalleled precision. This innovative leap not only vastly enhances precision and throughput compared to conventional gene sequencing methodologies but also holds profound significance for critical clinical applications such as NIPT, oncology, and tNGS. Furthermore, this technology heralds a new era of technological breakthroughs, offering unprecedented opportunities for a myriad of emerging applications, including early screening initiatives .

GeneSense AI deep learning analysis algorithm

Unique Technology For Primary Analysis Pipeline

Intelligent analysis process powered by GeneSense AI+ NGS technology

Primary Analysis

Production of genomic sequencing data

Fast Q

improve accuracy and throughput from the source.

Secondary Analysis

Mapping, Identification of genetic variants

variant calling – Enhance the accuracy of variant detection.

Tertiary Analysis

Generate evidence for clinical decision-making

Clinical Report

Effectively improve the precision of the final diagnostic report.

Advantages

More precise

Higher throughput

Lower cost

GeneSense’s cutting-edge AI+ NGS technology

Pioneering a new era of technological breakthroughs for various emerging applications including early screening, e.g.

Early screening based on DNA sequencing

With the aid of precise sequencing technology and AI-powered data analytics, low-frequency mutations in blood, tissue or other biological samples can be detected.
Through comprehensive detection of multiple genetic variations and methylation statuses, the patient's risk of tumor development can be systematically assessed and accurate screening results can be provided in the early stages of the disease, offering robust support for clinicians to formulate prevention or treatment strategies.

Protein multiomics cancer diagnosis

Using innovative customized assay kits and advanced experimental procedures, integrated with AI deep learning algorithms, enables precise and comprehensive analysis of complex protein expression profiles. Through in-depth investigation of cancer-associated biomarkers, aberrant protein expressions occurring throughout tumor progression are elucidated, facilitating refined molecular subtyping and prognosis assessment. This empowers clinical practitioners in the design and optimization of personalized diagnostic and therapeutic strategies.

StarSeq 100

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The industry's first high

throughput gene sequencer equipped with AI deep learning algorithm technology

More advanced NGS technologies

Integrated optical waveguide technology

Integrated optical waveguide technology achieves high precision, integration and miniaturization of optical systems by manufacturing sub-micron scale optical waveguide structures on chips. In the field of biological sequencing, the introduction of optical waveguides to replace traditional optical excitation structures can significantly improve the excitation signal-to-noise ratio, reduce the sensitivity requirements for bio-marker detection, and achieve single-molecule excitation. Combined with integrated CMOS image sensing technology, this enables the construction of high-throughput, high-precision, and low-cost sequencing and protein detection platforms on micro/nano chips.

Dual Flowcell Technology

The GeneSense NGS gene sequencer adopts a dual Flowcell design to achieve a parallel operation mode: conducting efficient biochemical reactions while simultaneously performing precise optical imaging. This cleverly doubles the overall system output efficiency without extending the sequencing time, significantly enhacing throughput performance. In addition, GeneSense also implements two independent and flexible temperature control functions of Flowcell, allowing customization of the most appropriate chemical reaction conditions according to different experimental requirements. This also ensures that each sequencing process can operate in the ooptimal environment, resulting in higher sequencing accuracy and quality standards.

Microfluidic Technology

Genesense has capability to design and manufacture state of the art microfluidic chip. The miniaturized microfluidic systems can achieve aims of reduced reagent consumption, automation of various fluid delivery steps, with integration of optical and thermal sub-systems. The systematic risk assessment of the integration between different modules will be conducted to achieve high yield during batch production of the microfluidic delivery system. Genesense has a wealth of experience for testing of the fluid delivery functionality and troubleshooting fluidic related issue to ensure fluid delivery efficiency and stability. Various functions can be implemented in microfluidic systems including sample purification, dilution etc.